BER Structural Biology and Imaging Resources
Synchrotron, Neutron, and Cryo-EM
U.S. Department of Energy | Office of Science | Office of Biological and Environmental Research

Research at the Advanced Photon Source Leads to New Ebola Drug

December 9, 2019

Feature Story

The ability to examine how specific antibodies react can lead to treatments for deadly diseases and often depends on determining how proteins in our bodies behave. Research at Argonne National Laboratory’s Advanced Photon Source enables these insights and has led to the development of a promising drug for Ebola. Using specialized beamlines, researchers revealed how two human antibodies were able to neutralize the virus by examining single-crystal samples of a complex combining the Ebola protein with the protective antibodies. A drug based on one of these antibodies proved remarkably effective during a recent Ebola outbreak and clinical trials in the Democratic Republic of Congo.

Misasi, J., et al. 2016. “Structural and Molecular Basis for Ebola Virus Neutralization by Protective Human Antibodies,” Science 351(6279), 1343–46. [DOI:10.1126/science.aad6117]