BER Structural Biology and Imaging Resources
Synchrotron, Neutron, and Cryo-EM
U.S. Department of Energy | Office of Science | Office of Biological and Environmental Research

Highlights

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DateTitleTechniqueFacilityScience Topic
10/30/2020Molecular Crystals Hybridized with Hydrogel Polymers Achieve Unprecedented Material Attributes
01/07/2020Multistep Crystallization of Microbial S-Layers
03/23/2020Antibiotics with a Built-in OFF Switch
11/02/2020Mechanistic Insights into Cu(I) Biogenesis of Galactose Oxidase
09/01/2020Tracking Foliar Zinc Absorption in Apple Trees
01/01/2021Soil Amendments and Flooding Cycle Impact Cadmium Bioavailability in Paddy Soil
08/18/2020Visualizing Enzymes in Action
01/22/2020Efficient and Economical Strategy for Functional Metalloprotein Design
03/10/2020Introducing Positive Charges in an Artificial Enzyme Increases CO2 Hydrogenation
12/09/2019Tuning the Catalytic Bias of Hydrogenase Enzymes
03/08/2018Safety Concerns Over Tungsten Accumulation in Bone
07/08/2019Nanoparticle Properties Influence Transport and Distribution in Plants
10/17/20183.7-Billion-Year-Old Rock Structures Formed by Tectonics, Not Life
09/07/2018First X-ray Nanofluorescence Tomography of Single Bacterial Cell
12/10/2018Nanoparticle Surface Chemistry Influences Journey Through Tomato Plant
11/07/2017Characterization of Elusive Yeast Protein Complex Involved in Autophagy
03/24/2020Critical Structural Differences Between Seasonal and Pandemic Influenza
03/24/2020Tunable Molecular Coating Stabilizes "DNA Origami" Structures
05/16/2019Key Drug Target Shown Assembling in Real Time
06/17/2021Surface Features of Prions Reveal Mechanism of Replication
01/10/2018Novel Architecture of a Bacterial Plasma Membrane Transporter
11/16/20173D Protein Structure Aids Search for Vaccine
08/09/2018Activation Mechanism of a Protein Kinase Reveals Role in Cancer Proliferation
10/08/2018Searching for New Ways to Fight Bacterial Resistance
06/21/2019Light Teaches Coenzymes New TricksX-ray Macromolecular CrystallographyNational Synchrotron Light Source IIMolecular Structure
05/21/2019Structural Basis of Bacterial Spore GerminationX-ray Macromolecular CrystallographyNational Synchrotron Light Source IIMolecular Structure
05/07/2020Mechanism of Activation of a Plant MetacaspaseX-ray Macromolecular CrystallographyNational Synchrotron Light Source IIMolecular Structure
04/14/2021Molecular Fragment Screening Identifies Potential SARS-CoV-2 InhibitorsX-ray Macromolecular CrystallographyAdvanced Light Source, National Synchrotron Light Source II, Stanford Synchrotron Radiation LightsourceMolecular Structure
06/13/2018Structure of a Nuclear Membrane GatekeeperX-ray Macromolecular CrystallographyNational Synchrotron Light Source IIMolecular Structure
09/23/2019Mechanism of Regulatory Protein's Dual Role as Inhibitor and ActivatorX-ray Macromolecular CrystallographyNational Synchrotron Light Source II, Stanford Synchrotron Radiation LightsourceMolecular Structure
04/02/2013Major Scaffold Component in Nuclear Pore ComplexSolution X-ray ScatteringStanford Synchrotron Radiation LightsourceMolecular Structure
05/24/2012Modulation of Plant Hormones by GH3 ProteinsX-ray Macromolecular CrystallographyAdvanced Photon SourceMolecular Structure
10/29/2013Common Physical Processes in Different Biomass PretreatmentsSmall-Angle Neutron Scattering, X-ray Macromolecular CrystallographySpallation Neutron Source/High Flux Isotope ReactorMolecular Structure
07/17/2013Lessening X-ray Damage Speeds Protein DiscoveryX-ray Macromolecular CrystallographyAdvanced Photon SourceMolecular Structure
02/07/2013Lipid Bilayer Composition Regulates Function of Lipid Rafts in Model Cell MembranesSmall-Angle Neutron ScatteringSpallation Neutron Source/High Flux Isotope ReactorMolecular Structure
12/09/2012Watching the Evolution of a Protein’s FunctionX-ray Absorption and Emission SpectroscopyStanford Synchrotron Radiation LightsourceChemical and Elemental Information
08/15/2013Multifunctionality of an Ebola Virus ProteinX-ray Macromolecular CrystallographyAdvanced Light Source, Advanced Photon Source, Stanford Synchrotron Radiation LightsourceMolecular Structure
09/26/2014Understanding Nitrogen Fixation in BacteriaX-ray Macromolecular CrystallographyStanford Synchrotron Radiation LightsourceMolecular Structure
11/10/2014Self-Assembling Porous Protein Cage Designed for Potential Biotech ApplicationsSolution X-ray Scattering, X-ray Macromolecular CrystallographyAdvanced Light SourceMolecular Structure
08/25/2015Modular Construction on a Biomolecular ScaleX-ray Macromolecular CrystallographyStanford Synchrotron Radiation LightsourceMolecular Structure
06/10/2015Archaeal Enzyme Plays Key Role in Atmospheric Carbon TurnoverX-ray Macromolecular CrystallographyAdvanced Photon SourceMolecular Structure
09/08/2015Manganese Reduction-Oxidation Drives Plant Debris DecompositionSynchrotron Infrared Hyperspectral Imaging, X-ray Absorption and Emission Spectroscopy, X-ray Fluorescence ImagingAdvanced Light Source, Stanford Synchrotron Radiation LightsourceChemical and Elemental Information
12/07/2016Using Soft X-ray Ptychography to Investigate a Bacterium’s Inner CompassX-ray Absorption and Emission SpectroscopyAdvanced Light SourceChemical and Elemental Information
11/30/2016Crystal Structure of NOV1 Enzyme Reveals Mechanism of ActionX-ray Macromolecular CrystallographyAdvanced Light SourceMolecular Structure
11/15/2016Mapping the Migration of Genetic MaterialSoft X-ray TomographyAdvanced Light SourceCell and Tissue Structure
09/30/2020Understanding an Essential Chaperone ComplexCryo-Electron Microscopy, X-ray Macromolecular CrystallographyAdvanced Photon Source, National Synchrotron Light Source II, Stanford Synchrotron Radiation LightsourceMolecular Structure
07/31/2020Targeting a Critical Molecular Switch in COVID-19Solution X-ray ScatteringNational Synchrotron Light Source IIMolecular Structure
11/30/2020Fine Tuning Drugs to Fight CancerX-ray Macromolecular CrystallographyAdvanced Photon Source, National Synchrotron Light Source IIMolecular Structure
01/12/2016Cellulose Synthesis ComplexSmall-Angle Neutron Scattering, Solution X-ray ScatteringSpallation Neutron Source/High Flux Isotope ReactorMolecular Structure
12/14/2016Hollow Pyramid Unlocks Principles of Protein ArchitectureSolution X-ray ScatteringAdvanced Light SourceMolecular Structure
12/20/2016Detailing the Molecular Roots of Alzheimer’s DiseaseX-ray Macromolecular CrystallographyAdvanced Photon SourceMolecular Structure
08/15/2016How Your Body Transports Zinc to Protect Your HealthX-ray Macromolecular CrystallographyAdvanced Photon SourceMolecular Structure
07/20/2017The CRISPR Target-Recognition MechanismX-ray Macromolecular CrystallographyAdvanced Light Source, Stanford Synchrotron Radiation LightsourceMolecular Structure
05/03/2018Dynamic Regulation of Histone Chaperone NucleoplasminSolution X-ray ScatteringStanford Synchrotron Radiation LightsourceMolecular Structure
06/23/2017Revealing How Bacterial Organelles AssembleX-ray Macromolecular CrystallographyStanford Synchrotron Radiation LightsourceMolecular Structure
06/26/2017Molecular Basis of Alternative Tyrosine Biosynthesis in PlantsX-ray Macromolecular CrystallographyAdvanced Photon SourceMolecular Structure
04/12/2017Green Alga Genome Provides Blueprint to Advance Clean Energy, BioproductsSoft X-ray TomographyAdvanced Light SourceCell and Tissue Structure
10/06/2016Description of Hydration Water in Green Fluorescent Protein SolutionSmall-Angle Neutron ScatteringSpallation Neutron Source/High Flux Isotope ReactorMolecular Structure
09/29/2017Precise Control of Neutron Contrast in Surfactant Micelles Provides Platform for Membrane Structure StudiesSmall-Angle Neutron ScatteringSpallation Neutron Source/High Flux Isotope ReactorMolecular Structure
12/22/2016Neutrons Identify Oxygen Activation in LPMO enzymeNeutron Macromolecular Crystallography, X-ray Macromolecular CrystallographyAdvanced Photon Source, Spallation Neutron Source/High Flux Isotope ReactorMolecular Structure
05/23/2017Using Neutrons to Resolve Plasma Membrane Organization in Live BacteriaSmall-Angle Neutron ScatteringSpallation Neutron Source/High Flux Isotope ReactorMolecular Structure
08/03/2017Chemical Strategy for Conversion of CO2 to BiomassX-ray Macromolecular CrystallographyAdvanced Photon Source, Stanford Synchrotron Radiation LightsourceMolecular Structure
11/19/2020Enhancing Enzyme Catalysis Through Directed EvolutionX-ray Macromolecular CrystallographyStanford Synchrotron Radiation LightsourceMolecular Structure
08/14/2020Phenoxy Radical-Radical Coupling in PlantsX-ray Macromolecular CrystallographyStanford Synchrotron Radiation LightsourceMolecular Structure
06/22/2017Archaeal Abundance on Human Skin Associates with AgeSynchrotron Infrared Hyperspectral ImagingAdvanced Light SourceChemical and Elemental Information
08/11/2017Hacking the Bacterial Social NetworkX-ray Macromolecular CrystallographyAdvanced Photon SourceMolecular Structure
06/16/2017Engineering Better Plant Cultivars for Iron Uptake by Modifying the Iron Deficiency Response in Arabidopsis thalianaX-ray Fluorescence ImagingAdvanced Photon Source, National Synchrotron Light Source II, Stanford Synchrotron Radiation LightsourceChemical and Elemental Information
05/09/2017Probing S-layer Protein Structural Dynamics with SAXSSolution X-ray ScatteringStanford Synchrotron Radiation LightsourceMolecular Structure
09/08/2017The Origins of Photosynthesis in a Sun-Loving BacteriaX-ray Macromolecular CrystallographyAdvanced Light Source, Advanced Photon SourceMolecular Structure
08/14/2017X-ray Footprinting Solves Mystery of Metal-Breathing ProteinAdvanced Light SourceMolecular Structure
12/05/2016Designing Cyclic Oligomers: Greater than the Sum of Their PartsSolution X-ray Scattering, X-ray Macromolecular CrystallographyAdvanced Light Source, Advanced Photon SourceMolecular Structure
09/09/2017Measuring and Modeling Poplar Root Water Extraction After Drought Using Neutron ImagingNeutron ImagingSpallation Neutron Source/High Flux Isotope ReactorCell and Tissue Structure
06/30/2017Finding New Clues to a Common Respiratory VirusX-ray Macromolecular CrystallographyAdvanced Photon SourceMolecular Structure
11/02/2017Arsenic Accumulation in Benthic Periphytic BiofilmsX-ray Fluorescence ImagingStanford Synchrotron Radiation LightsourceChemical and Elemental Information
10/01/2016Crystal Clear Imaging Infrared Brings to Light Nanoscale Molecular ArrangementSynchrotron Infrared Hyperspectral ImagingAdvanced Light SourceChemical and Elemental Information
07/10/2017Novel Orange Carotenoid Proteins Shed Light on Evolution of Cyanobacteria PhotoprotectionX-ray Macromolecular CrystallographyAdvanced Light SourceMolecular Structure
01/11/2017Study Pinpoints Most Active Areas of Reactions on Nanoscale ParticlesSynchrotron Infrared Hyperspectral ImagingAdvanced Light SourceChemical and Elemental Information
01/19/2017A Regional Model for Uranium Redox and MobilityX-ray Absorption and Emission SpectroscopyStanford Synchrotron Radiation LightsourceChemical and Elemental Information
04/07/2017Direct Measurement of Protein Dynamics In VivoSmall-Angle Neutron ScatteringSpallation Neutron Source/High Flux Isotope ReactorMolecular Structure
04/18/2017Could This Enzyme Help Turn Biofuel Waste into Something Useful?X-ray Macromolecular CrystallographyAdvanced Light SourceMolecular Structure
07/11/2017Brown Rot Fungi Reveal a New Approach for Biomass Conversion to Fuels and ChemicalsSmall-Angle Neutron ScatteringSpallation Neutron Source/High Flux Isotope ReactorMolecular Structure
09/19/2019Dynamics on Cellulose Show Two Important Populations from Neutron Scattering and SimulationsSmall-Angle Neutron ScatteringSpallation Neutron Source/High Flux Isotope ReactorMolecular Structure
11/15/2017Cyanobacterial Studies Examine Cellular Structure During Nitrogen StarvationSmall-Angle Neutron ScatteringSpallation Neutron Source/High Flux Isotope ReactorMolecular Structure
12/13/2017Binding of Alternative Substrates to NitrogenaseX-ray Macromolecular CrystallographyStanford Synchrotron Radiation LightsourceMolecular Structure
01/17/2018"Zip code" Mechanism for Hormone Signaling RevealedX-ray Macromolecular CrystallographyNational Synchrotron Light Source II, Stanford Synchrotron Radiation LightsourceMolecular Structure
01/18/2018Structure of a Flavoenzyme Assembly IntermediateX-ray Macromolecular CrystallographyStanford Synchrotron Radiation LightsourceMolecular Structure
12/14/2017Using Plants to Immobilize and Stabilize Arsenic in the SoilX-ray Absorption and Emission Spectroscopy, X-ray Fluorescence ImagingNational Synchrotron Light Source II, Stanford Synchrotron Radiation LightsourceChemical and Elemental Information
08/30/2018Directed Evolution Mimics Allosteric Activation of EnzymesX-ray Macromolecular CrystallographyStanford Synchrotron Radiation LightsourceMolecular Structure
08/21/2018Potent BacteriaX-ray Macromolecular CrystallographyAdvanced Photon SourceMolecular Structure
11/15/2018Controlled Self-Assembly of a Designed NucleoproteinSolution X-ray ScatteringStanford Synchrotron Radiation LightsourceMolecular Structure
02/05/2019Peptide Induced Lateral Segregation of Lipids in a BiomembraneSmall-Angle Neutron ScatteringSpallation Neutron Source/High Flux Isotope ReactorMolecular Structure
02/25/2019Breakthrough Shines Light on Disease-Fighting ProteinCryo-Electron Microscopy, X-ray Macromolecular CrystallographyAdvanced Photon Source, Stanford Synchrotron Radiation LightsourceMolecular Structure
02/18/2019An Efficient and Economical Strategy for the Design of Functional MetalloproteinsX-ray Macromolecular CrystallographyStanford Synchrotron Radiation LightsourceMolecular Structure
02/22/2019DNA Gets a Bigger AlphabetX-ray Macromolecular CrystallographyStanford Synchrotron Radiation LightsourceMolecular Structure
03/05/2019Understanding Cadmium Distribution in Hyperaccumulating Plants for Efficient PhytoremediationX-ray Fluorescence ImagingStanford Synchrotron Radiation LightsourceChemical and Elemental Information
04/05/2019Influence of Chemically Disrupted Photosynthesis on Cyanobacterial Thylakoid DynamicsSmall-Angle Neutron ScatteringSpallation Neutron Source/High Flux Isotope ReactorMolecular Structure
04/12/2019What Enables the Fastest Carbon Dioxide Fixation by Reductive Carboxylase?X-ray Macromolecular CrystallographyStanford Synchrotron Radiation LightsourceMolecular Structure
05/03/2019New Approach for Solving Protein Structures from Tiny CrystalsX-ray Macromolecular CrystallographyNational Synchrotron Light Source IIMolecular Structure
07/10/2019Structuring Sweetness: What Makes Stevia 200 Times Sweeter than Sugar?X-ray Macromolecular CrystallographyAdvanced Photon SourceMolecular Structure
07/10/2019Structural Characterization of Chitinases from Agave tequilanaSolution X-ray ScatteringStanford Synchrotron Radiation LightsourceMolecular Structure
11/19/2019How Essential Membrane Lipids Interact to Regulate Cellular ProcessesX-ray Macromolecular CrystallographyAdvanced Photon SourceMolecular Structure
11/29/2019Ammonia-Salt Solvent Promotes Cellulosic Biomass Deconstruction Under Ambient Processing ConditionsSmall-Angle Neutron ScatteringSpallation Neutron Source/High Flux Isotope ReactorMolecular Structure
12/09/2019Research at the Advanced Photon Source Leads to New Ebola DrugX-ray Macromolecular CrystallographyAdvanced Photon SourceMolecular Structure
08/29/2020How Proteins Remodel DNA in Bacteria Under StressSolution X-ray Scattering, X-ray Macromolecular Crystallography, Soft X-ray TomographyAdvanced Light SourceMolecular Structure, Cell and Tissue Structure
08/13/2020Cell Membrane Proteins Imaged in 3DX-ray Fluorescence ImagingAdvanced Photon Source, National Synchrotron Light Source IIChemical and Elemental Information
07/21/2020Role of Solvents in Efficient Biomass DeconstructionSmall-Angle Neutron ScatteringSpallation Neutron Source/High Flux Isotope ReactorMolecular Structure
02/14/2020Revealing How Dinosaur Blood Vessels Preserve Through the AgesSynchrotron Infrared Hyperspectral ImagingAdvanced Light SourceChemical and Elemental Information
06/23/2020Novel Cell Membrane Model Could Be Key to Uncovering New Protein PropertiesCryo-Electron Microscopy, Small-Angle Neutron Scattering, Solution X-ray ScatteringNational Synchrotron Light Source II, Spallation Neutron Source/High Flux Isotope ReactorMolecular Structure, Cell and Tissue Structure
10/07/2020"Missing Link" in Evolutionary History of the Carbon-Fixing Protein RubiscoSolution X-ray ScatteringAdvanced Light SourceMolecular Structure