Structural Biology Center

About the Resource

SBC crystallographer Karolina Michalska working on SARS-CoV-2 proteins at the 19-ID beamline.

The Structural Biology Center (SBC) is a resource for X-ray macromolecular crystallography (MX) and other complementary techniques at Argonne National Laboratory’s Advanced Photon Source (APS). SBC research focuses on proteins relevant to BER missions (especially plant, fungal, and bacterial proteins) and on improving hardware and software for data collection at synchrotron beamlines. SBC offers efficient data collection and structure determination systems for regular and serial protein crystallography. Researchers have deposited more than 6,100 structures in the Protein Data Bank using data measured at SBC and have produced more than 2,500 publications.

SBC operates two beamlines at APS’s Sector 19—one insertion device (19-ID) and one bending magnet (19-BM)—that provide powerful and productive X-ray sources for structural biology research. Both can be accessed onsite or remotely for experiments, structure analysis, and data backup.

The beamlines can deliver very low angular divergence X-ray micro-beams onto micrometer-size crystal samples mounted using robotic systems, thereby enabling scientists to use crystallography to study the structures of large and complex molecular systems at atomic resolution. The X-ray beam on 19-ID can be further focused to micrometer sizes using a compound refractive lens. High quality data can be collected from millimeter to micrometer-sized crystals of individual proteins, protein complexes, macromolecular assemblies, and membrane proteins. Small crystals can be used for dynamic room temperature serial crystallography to study ligand binding and chemical transformations.

Diffraction from these crystals is recorded on large, fast (up to 50 images per second), efficient area detectors and is processed on integrated computing systems with advanced control and data analysis software designed specifically for SBC. The integrated robotics of sample mounting and the automation of data collection and structure determination lower the training barrier for beamline use and enable remote access on both beamlines.

At SBC, all aspects of a crystallographic experiment—including X-ray energy, crystal decay, and signal-to-noise ratio—can be optimized. Data can be processed and structures determined using semi-automated approaches in near-real time, in many cases. 19-ID accommodates data collection from samples in situ and in cellulo, enabling the study of proteins and complexes under close to physiological conditions.

The use of SBC beamlines at the Advanced Photon Source is supported by BER and operated for the DOE Office of Science by Argonne National Laboratory under Contract No. DEAC02-06CH11357.

About the Home Facility

The Advanced Photon Source is a DOE scientific user facility at Argonne National Laboratory sponsored by the Basic Energy Sciences Program. APS provides ultra-bright, high-energy, storage-ring-generated X-ray beams for research in almost all scientific disciplines.

Unique properties of APS synchrotron radiation include its continuous X-ray spectrum, high flux and brightness, and high coherence, which make APS an indispensable tool for exploring matter. The wavelengths of its emitted photons can probe a range of sample dimensions from the atomic scale to entire cells and tissues, thereby providing incisive probes for advanced research in materials science, physical and chemical sciences, metrology, geosciences, environmental sciences, biosciences, medical sciences, and pharmaceutical sciences.

APS will be upgraded (APS-U) in 2023 to a multi-bend achromat lattice which will deliver the ultimate diffraction-limited X-ray source with radically transformative capabilities. The specific advantages of the APS-U X-ray source include:

  • Increased brightness allowing delivery of intense beams with dimensions of one micrometer or less, resulting in a 100-fold improvement in signal-to-noise.
  • Increased brightness at high energy (especially for energies 12 keV – 40 keV) that can be exploited to reduce primary radiation damage.
  • Low convergence X-ray beams essential to studying large macromolecular complexes at high resolution.

The expanded APS-U capabilities offer new opportunities such as tracking protein conformational changes in real time by simultaneously recording structural and kinetic data to understand correlations between molecular motions and chemistry in catalysis.

Other APS Capabilities

APS offers more than 60 beamlines that can be applied to broad range of experimental conditions. The complete listing of contacts, specifications, and status for all APS beamlines is available on the APS website.

Three broad categories of experimental techniques are available at APS:

  • Scattering utilizes patterns of light produced when X-rays are deflected by the closely-spaced lattice of atoms in solids. This technique is commonly used to determine the structures of crystals and large molecules such as proteins.
  • Imaging techniques use the light-source beam to visualize samples at fine spatial resolutions. These techniques are applied in diverse research areas, including cell biology, lithography, infrared microscopy, radiology, and X-ray tomography.
  • Spectroscopy reveals the energies of particles emitted or absorbed by samples exposed to the light-source beam. This technique is commonly used to determine the characteristics of chemical bonding and electron motion.

SBC and other major research projects with a focus on biological systems, dynamics, synthetic biology, and structural biology take advantage of Argonne National Laboratory’s Advanced Protein Characterization Facility (APCF) located at Sector 84 of APS. APCF establishes state-of-the-art laboratories integrated with a scientific collaboration facility for protein production, characterization, and crystallization.

APCF efficiently delivers crystals to APS’ powerful X-ray beamlines and takes full advantage of Argonne’s facilities for determining three-dimensional structures of proteins and other biological macromolecules. APCF also characterizes protein functions and studies their interactions with other macromolecules and small ligands.

Research Highlights

DateTitleResourceTechniqueFacilityResearch Theme
02/22/2021Repurposing Cancer and Seizure Medications to Aid Fight Against COVID-19Structural Biology CenterX-ray Macromolecular CrystallographyAdvanced Photon SourceMolecular Structure
06/11/2020Structural Basis for Neutralization of Betacoronaviruses by Llama AntibodiesStructural Biology CenterX-ray Macromolecular CrystallographyAdvanced Photon SourceMolecular Structure
08/19/2021Existing Drug Inhibits SARS-CoV-2 ReplicationStructural Biology CenterX-ray Macromolecular CrystallographyAdvanced Photon SourceMolecular Structure
08/03/2021Deconstructing the Infection Machinery of SARS-CoV-2Center for Structural Molecular Biology, Structural Biology Center, Structurally Integrated Biology for the Life SciencesSmall-Angle Neutron Scattering, Solution X-ray Scattering, X-ray Macromolecular CrystallographyAdvanced Light Source, Advanced Photon Source, Spallation Neutron Source/High Flux Isotope ReactorMolecular Structure
05/12/2021Crystallography Confirms Drug-Protein Interaction that May Prevent Certain Breast CancersStructural Biology CenterX-ray Macromolecular CrystallographyAdvanced Photon SourceMolecular Structure
04/17/2020Crystal Structures of SARS-CoV-2 Yield Understanding of Viral Replication EngineStructural Biology CenterX-ray Macromolecular CrystallographyAdvanced Photon SourceMolecular Structure
05/01/2021Structural Plasticity of the Selectivity Filter in a Nonselective Ion ChannelStructural Biology CenterX-ray Macromolecular CrystallographyAdvanced Photon SourceMolecular Structure
10/05/2021Study Sheds Light on Photosynthesis in Iron-Low LeavesCenter for BioMolecular StructureX-ray Fluorescence ImagingNational Synchrotron Light Source IIChemical and Elemental Information
02/11/2021A Modular Approach to Designing Protein AssembliesStructurally Integrated Biology for the Life SciencesSolution X-ray ScatteringAdvanced Light SourceMolecular Structure
01/19/2021Fusion Enzymes Improve Yield of Functionalized TerpenesStructurally Integrated Biology for the Life SciencesSolution X-ray ScatteringAdvanced Light SourceMolecular Structure
01/06/2021Designing a Controllable Self-Assembling BiomaterialStructurally Integrated Biology for the Life SciencesSolution X-ray ScatteringAdvanced Light SourceMolecular Structure
02/03/2020Antibodies Elicited by Zika Vaccine CharacterizedCenter for BioMolecular Structure, Structural Biology CenterX-ray Macromolecular CrystallographyAdvanced Photon Source, National Synchrotron Light Source IIMolecular Structure
09/24/2019Revealing a MERS-CoV VulnerabilityStructural Biology CenterX-ray Macromolecular CrystallographyAdvanced Photon SourceMolecular Structure
10/27/2020Potent Antibody Against SARS-CoV-2Structural Biology CenterX-ray Macromolecular CrystallographyAdvanced Photon SourceMolecular Structure
02/02/2021SARS-CoV-2 Enzyme Structure Reveals Potential InhibitorsStructural Biology CenterX-ray Macromolecular CrystallographyAdvanced Photon SourceMolecular Structure
05/21/2021Essential Enzyme in Bacterial Protein SynthesisStructural Biology CenterX-ray Macromolecular CrystallographyAdvanced Photon SourceMolecular Structure
06/02/2021Complexation of Metals with Bacterial MethanobactinsStructural Molecular Biology ResourceX-ray Absorption and Emission SpectroscopyStanford Synchrotron Radiation LightsourceChemical and Elemental Information
03/24/2021Deciphering the Mechanism of Enzymatic Methane SynthesisStructural Molecular Biology ResourceX-ray Absorption and Emission Spectroscopy, X-ray Fluorescence ImagingStanford Synchrotron Radiation LightsourceChemical and Elemental Information
10/30/2020Molecular Crystals Hybridized with Hydrogel Polymers Achieve Unprecedented Material AttributesStructural Molecular Biology ResourceSolution X-ray Scattering, X-ray Macromolecular CrystallographyStanford Synchrotron Radiation LightsourceMolecular Structure
01/07/2020Multistep Crystallization of Microbial S-LayersStructurally Integrated Biology for the Life Sciences, Structural Molecular Biology ResourceCryo-Electron Microscopy, Solution X-ray Scattering, X-ray Macromolecular CrystallographyAdvanced Light Source, Stanford Synchrotron Radiation LightsourceMolecular Structure
03/23/2020Antibiotics with a Built-in OFF SwitchStructural Molecular Biology ResourceSolution X-ray Scattering, Synchrotron Infrared Hyperspectral ImagingStanford Synchrotron Radiation LightsourceMolecular Structure, Chemical and Elemental Information
11/02/2020Mechanistic Insights into Cu(I) Biogenesis of Galactose OxidaseStructural Molecular Biology ResourceX-ray Absorption and Emission SpectroscopyStanford Synchrotron Radiation LightsourceChemical and Elemental Information
09/01/2020Tracking Foliar Zinc Absorption in Apple TreesStructural Molecular Biology ResourceX-ray Fluorescence ImagingAdvanced Photon Source, Stanford Synchrotron Radiation LightsourceChemical and Elemental Information
01/01/2021Soil Amendments and Flooding Cycle Impact Cadmium Bioavailability in Paddy SoilStructural Molecular Biology ResourceX-ray Absorption and Emission SpectroscopyStanford Synchrotron Radiation LightsourceChemical and Elemental Information
08/18/2020Visualizing Enzymes in ActionStructural Molecular Biology ResourceX-ray Macromolecular CrystallographyStanford Synchrotron Radiation LightsourceMolecular Structure
01/22/2020Efficient and Economical Strategy for Functional Metalloprotein DesignStructural Molecular Biology ResourceCryo-Electron Microscopy, X-ray Macromolecular CrystallographyStanford Synchrotron Radiation LightsourceMolecular Structure
03/10/2020Introducing Positive Charges in an Artificial Enzyme Increases CO2 HydrogenationStructural Molecular Biology ResourceX-ray Macromolecular CrystallographyEnvironmental Molecular Sciences Laboratory, Stanford Synchrotron Radiation LightsourceMolecular Structure
12/09/2019Tuning the Catalytic Bias of Hydrogenase EnzymesStructural Molecular Biology ResourceX-ray Macromolecular Crystallography, Synchrotron Infrared Hyperspectral ImagingEnvironmental Molecular Sciences Laboratory, Stanford Synchrotron Radiation LightsourceMolecular Structure, Chemical and Elemental Information
03/08/2018Safety Concerns Over Tungsten Accumulation in BoneCenter for BioMolecular StructureX-ray Fluorescence ImagingNational Synchrotron Light Source IIChemical and Elemental Information
07/08/2019Nanoparticle Properties Influence Nutrient Transport in PlantsCenter for BioMolecular Structure, Structural Molecular Biology ResourceX-ray Absorption and Emission Spectroscopy, X-ray Fluorescence ImagingNational Synchrotron Light Source II, Stanford Synchrotron Radiation LightsourceChemical and Elemental Information
10/17/20183.7-Billion-Year-Old Rock Structures Formed by Tectonics, Not LifeCenter for BioMolecular StructureX-ray Fluorescence ImagingNational Synchrotron Light Source IIChemical and Elemental Information
09/07/2018X-ray Nanofluorescence Tomography of Single Bacterial CellsCenter for BioMolecular StructureX-ray Fluorescence ImagingNational Synchrotron Light Source IIChemical and Elemental Information
12/10/2018Nanoparticle Surface Chemistry Influences Journey Through Tomato PlantCenter for BioMolecular StructureX-ray Fluorescence ImagingNational Synchrotron Light Source IIChemical and Elemental Information
11/07/2017Characterization of Elusive Yeast Protein Complex Involved in AutophagyCenter for BioMolecular StructureSolution X-ray ScatteringNational Synchrotron Light Source IIMolecular Structure
03/24/2020Critical Structural Differences Between Seasonal and Pandemic InfluenzaCenter for BioMolecular StructureSolution X-ray Scattering, X-ray Macromolecular CrystallographyNational Synchrotron Light Source IIMolecular Structure
03/24/2020Tunable Molecular Coating Stabilizes "DNA Origami" StructuresCenter for BioMolecular StructureSolution X-ray ScatteringNational Synchrotron Light Source IIMolecular Structure
01/10/2018Novel Architecture of a Bacterial Plasma Membrane TransporterCenter for BioMolecular StructureX-ray Macromolecular CrystallographyNational Synchrotron Light Source IIMolecular Structure
11/16/20173D Protein Structure Aids Search for VaccineCenter for BioMolecular StructureX-ray Macromolecular CrystallographyNational Synchrotron Light Source IIMolecular Structure
08/09/2018Activation Mechanism of a Protein Kinase Reveals Role in Cancer ProliferationCenter for BioMolecular StructureX-ray Macromolecular CrystallographyNational Synchrotron Light Source IIMolecular Structure
10/08/2018Searching for New Ways to Fight Bacterial ResistanceCenter for BioMolecular StructureX-ray Macromolecular CrystallographyNational Synchrotron Light Source IIMolecular Structure
06/21/2019Light Teaches Coenzymes New TricksCenter for BioMolecular StructureX-ray Macromolecular CrystallographyNational Synchrotron Light Source IIMolecular Structure
05/21/2019Structural Basis of Bacterial Spore GerminationCenter for BioMolecular StructureX-ray Macromolecular CrystallographyNational Synchrotron Light Source IIMolecular Structure
05/07/2020Mechanism of Activation of a Plant MetacaspaseCenter for BioMolecular StructureX-ray Macromolecular CrystallographyNational Synchrotron Light Source IIMolecular Structure
04/14/2021Molecular Fragment Screening Identifies Potential SARS-CoV-2 InhibitorsCenter for BioMolecular Structure, Structurally Integrated Biology for the Life Sciences, Structural Molecular Biology ResourceX-ray Macromolecular CrystallographyAdvanced Light Source, National Synchrotron Light Source II, Stanford Synchrotron Radiation LightsourceMolecular Structure
06/13/2018Structure of a Nuclear Membrane GatekeeperCenter for BioMolecular StructureX-ray Macromolecular CrystallographyNational Synchrotron Light Source IIMolecular Structure
09/23/2019Mechanism of Regulatory Protein's Dual Role as Inhibitor and ActivatorCenter for BioMolecular StructureX-ray Macromolecular CrystallographyNational Synchrotron Light Source II, Stanford Synchrotron Radiation LightsourceMolecular Structure
04/02/2013Major Scaffold Component in Nuclear Pore ComplexStructural Molecular Biology ResourceSolution X-ray ScatteringStanford Synchrotron Radiation LightsourceMolecular Structure
05/24/2012Modulation of Plant Hormones by GH3 ProteinsStructural Biology CenterX-ray Macromolecular CrystallographyAdvanced Photon SourceMolecular Structure
10/29/2013Common Physical Processes in Different Biomass PretreatmentsCenter for Structural Molecular BiologySmall-Angle Neutron Scattering, X-ray Macromolecular CrystallographySpallation Neutron Source/High Flux Isotope ReactorMolecular Structure
07/17/2013Lessening X-ray Damage Speeds Protein DiscoveryStructural Biology CenterX-ray Macromolecular CrystallographyAdvanced Photon SourceMolecular Structure
02/07/2013Lipid Bilayer Composition Regulates Function of Lipid Rafts in Model Cell MembranesCenter for Structural Molecular BiologySmall-Angle Neutron ScatteringSpallation Neutron Source/High Flux Isotope ReactorMolecular Structure
12/09/2012Watching the Evolution of a Protein’s FunctionStructural Molecular Biology ResourceX-ray Absorption and Emission SpectroscopyStanford Synchrotron Radiation LightsourceChemical and Elemental Information
08/15/2013Multifunctionality of an Ebola Virus ProteinStructural Biology Center, Structural Molecular Biology ResourceX-ray Macromolecular CrystallographyAdvanced Light Source, Advanced Photon Source, Stanford Synchrotron Radiation LightsourceMolecular Structure
09/26/2014Understanding Nitrogen Fixation in BacteriaStructural Molecular Biology ResourceX-ray Macromolecular CrystallographyStanford Synchrotron Radiation LightsourceMolecular Structure
11/10/2014Self-Assembling Porous Protein Cage Designed for Potential Biotech ApplicationsStructurally Integrated Biology for the Life SciencesSolution X-ray Scattering, X-ray Macromolecular CrystallographyAdvanced Light SourceMolecular Structure
08/25/2015Modular Construction on a Biomolecular ScaleStructural Molecular Biology ResourceX-ray Macromolecular CrystallographyStanford Synchrotron Radiation LightsourceMolecular Structure
06/10/2015Archaeal Enzyme Plays Key Role in Atmospheric Carbon TurnoverStructural Biology CenterX-ray Macromolecular CrystallographyAdvanced Photon SourceMolecular Structure
09/08/2015Manganese Reduction-Oxidation Drives Plant Debris DecompositionBerkeley Synchrotron Infrared Structural Biology Imaging Program, Structural Molecular Biology ResourceSynchrotron Infrared Hyperspectral Imaging, X-ray Absorption and Emission Spectroscopy, X-ray Fluorescence ImagingAdvanced Light Source, Stanford Synchrotron Radiation LightsourceChemical and Elemental Information
12/07/2016Using Soft X-ray Ptychography to Investigate a Bacterium’s Inner CompassX-ray Absorption and Emission SpectroscopyAdvanced Light SourceChemical and Elemental Information
11/30/2016Crystal Structure of NOV1 Enzyme Reveals Mechanism of ActionStructurally Integrated Biology for the Life SciencesX-ray Macromolecular CrystallographyAdvanced Light SourceMolecular Structure
11/15/2016Mapping the Migration of Genetic MaterialNational Center for X-Ray TomographySoft X-ray TomographyAdvanced Light SourceCell and Tissue Structure
09/30/2020Understanding an Essential Chaperone ComplexStructural Molecular Biology ResourceCryo-Electron Microscopy, Solution X-ray Scattering, X-ray Macromolecular CrystallographyAdvanced Photon Source, National Synchrotron Light Source II, Stanford Synchrotron Radiation LightsourceMolecular Structure
07/31/2020Targeting a Critical Molecular Switch in COVID-19Center for BioMolecular StructureSolution X-ray ScatteringNational Synchrotron Light Source IIMolecular Structure
11/30/2020Fine Tuning Drugs to Fight CancerCenter for BioMolecular Structure, Structural Biology CenterX-ray Macromolecular CrystallographyAdvanced Photon Source, National Synchrotron Light Source IIMolecular Structure
01/12/2016Cellulose Synthesis ComplexCenter for Structural Molecular BiologySmall-Angle Neutron Scattering, Solution X-ray ScatteringSpallation Neutron Source/High Flux Isotope ReactorMolecular Structure
12/14/2016Hollow Pyramid Unlocks Principles of Protein ArchitectureStructurally Integrated Biology for the Life SciencesSolution X-ray ScatteringAdvanced Light SourceMolecular Structure
12/20/2016Detailing the Molecular Roots of Alzheimer’s DiseaseStructural Biology CenterX-ray Macromolecular CrystallographyAdvanced Photon SourceMolecular Structure
08/15/2016How Your Body Transports Zinc to Protect Your HealthStructural Biology CenterX-ray Macromolecular CrystallographyAdvanced Photon SourceMolecular Structure
07/20/2017The CRISPR Target-Recognition MechanismStructural Molecular Biology ResourceX-ray Macromolecular CrystallographyAdvanced Light Source, Stanford Synchrotron Radiation LightsourceMolecular Structure
05/03/2018Dynamic Regulation of Histone Chaperone NucleoplasminStructural Molecular Biology ResourceSolution X-ray ScatteringStanford Synchrotron Radiation LightsourceMolecular Structure
06/23/2017Revealing How Bacterial Organelles AssembleStructural Molecular Biology ResourceX-ray Macromolecular CrystallographyStanford Synchrotron Radiation LightsourceMolecular Structure
06/26/2017Molecular Basis of Alternative Tyrosine Biosynthesis in PlantsStructural Biology CenterX-ray Macromolecular CrystallographyAdvanced Photon SourceMolecular Structure
04/12/2017Green Alga Genome Provides Blueprint to Advance Clean Energy, BioproductsNational Center for X-Ray TomographySoft X-ray TomographyAdvanced Light SourceCell and Tissue Structure
10/06/2016Description of Hydration Water in Green Fluorescent Protein SolutionCenter for Structural Molecular BiologySmall-Angle Neutron ScatteringSpallation Neutron Source/High Flux Isotope ReactorMolecular Structure
09/29/2017Precise Control of Neutron Contrast in Surfactant Micelles Provides Platform for Membrane Structure StudiesCenter for Structural Molecular BiologySmall-Angle Neutron ScatteringSpallation Neutron Source/High Flux Isotope ReactorMolecular Structure
12/22/2016Neutrons Identify Oxygen Activation in LPMO enzymeCenter for Structural Molecular BiologyNeutron Macromolecular Crystallography, X-ray Macromolecular CrystallographyAdvanced Photon Source, Spallation Neutron Source/High Flux Isotope ReactorMolecular Structure
05/23/2017Using Neutrons to Resolve Plasma Membrane Organization in Live BacteriaCenter for Structural Molecular BiologySmall-Angle Neutron ScatteringSpallation Neutron Source/High Flux Isotope ReactorMolecular Structure
08/03/2017Chemical Strategy for Conversion of CO2 to BiomassStructural Biology Center, Structural Molecular Biology ResourceX-ray Macromolecular CrystallographyAdvanced Photon Source, Stanford Synchrotron Radiation LightsourceMolecular Structure
11/19/2020Enhancing Enzyme Catalysis Through Directed EvolutionStructural Molecular Biology ResourceX-ray Macromolecular CrystallographyStanford Synchrotron Radiation LightsourceMolecular Structure
08/14/2020Phenoxy Radical-Radical Coupling in PlantsStructural Molecular Biology ResourceX-ray Macromolecular CrystallographyStanford Synchrotron Radiation LightsourceMolecular Structure
06/22/2017Archaeal Abundance on Human Skin Changes with AgeBerkeley Synchrotron Infrared Structural Biology Imaging ProgramSynchrotron Infrared Hyperspectral ImagingAdvanced Light SourceChemical and Elemental Information
08/11/2017Hacking the Bacterial Social NetworkStructural Biology CenterX-ray Macromolecular CrystallographyAdvanced Photon SourceMolecular Structure
06/16/2017Engineering Better Plant Cultivars for Iron Uptake by Modifying the Iron Deficiency Response in Arabidopsis thalianaStructural Molecular Biology ResourceX-ray Fluorescence ImagingAdvanced Photon Source, National Synchrotron Light Source II, Stanford Synchrotron Radiation LightsourceChemical and Elemental Information
05/09/2017Probing S-layer Protein Structural Dynamics with SAXSStructural Molecular Biology ResourceSolution X-ray ScatteringStanford Synchrotron Radiation LightsourceMolecular Structure
09/08/2017The Origins of Photosynthesis in a Sun-Loving BacteriaStructural Biology CenterX-ray Macromolecular CrystallographyAdvanced Light Source, Advanced Photon SourceMolecular Structure
08/14/2017X-ray Footprinting Solves Mystery of Metal-Breathing ProteinCenter for BioMolecular StructureX-ray FootprintingAdvanced Light SourceMolecular Structure
12/05/2016Designing Cyclic Oligomers: Greater than the Sum of Their PartsStructurally Integrated Biology for the Life SciencesSolution X-ray Scattering, X-ray Macromolecular CrystallographyAdvanced Light Source, Advanced Photon SourceMolecular Structure
09/09/2017Measuring and Modeling Poplar Root Water Extraction After Drought Using Neutron ImagingCenter for Structural Molecular BiologyNeutron ImagingSpallation Neutron Source/High Flux Isotope ReactorCell and Tissue Structure
06/30/2017Finding New Clues to a Common Respiratory VirusStructural Biology CenterX-ray Macromolecular CrystallographyAdvanced Photon SourceMolecular Structure
11/02/2017Arsenic Accumulation in Benthic Periphytic BiofilmsStructural Molecular Biology ResourceX-ray Fluorescence ImagingStanford Synchrotron Radiation LightsourceChemical and Elemental Information
10/01/2016Crystal Clear Imaging Infrared Brings to Light Nanoscale Molecular ArrangementBerkeley Synchrotron Infrared Structural Biology Imaging ProgramSynchrotron Infrared Hyperspectral ImagingAdvanced Light SourceChemical and Elemental Information
07/10/2017Novel Orange Carotenoid Proteins Shed Light on Evolution of Cyanobacteria PhotoprotectionStructurally Integrated Biology for the Life SciencesX-ray Macromolecular CrystallographyAdvanced Light SourceMolecular Structure
01/11/2017Study Pinpoints Most Reactive Areas of Nanoscale ParticlesBerkeley Synchrotron Infrared Structural Biology Imaging ProgramSynchrotron Infrared Hyperspectral ImagingAdvanced Light SourceChemical and Elemental Information
01/19/2017A Regional Model for Uranium Redox and MobilityStructural Molecular Biology ResourceX-ray Absorption and Emission SpectroscopyStanford Synchrotron Radiation LightsourceChemical and Elemental Information
04/07/2017Direct Measurement of Protein Dynamics In VivoCenter for Structural Molecular BiologySmall-Angle Neutron ScatteringSpallation Neutron Source/High Flux Isotope ReactorMolecular Structure
04/18/2017Could This Enzyme Help Turn Biofuel Waste into Something Useful?Structurally Integrated Biology for the Life SciencesX-ray Macromolecular CrystallographyAdvanced Light SourceMolecular Structure
07/11/2017Brown Rot Fungi Reveal a New Approach for Biomass Conversion to Fuels and ChemicalsCenter for Structural Molecular BiologySmall-Angle Neutron ScatteringSpallation Neutron Source/High Flux Isotope ReactorMolecular Structure
09/19/2019Dynamics on Cellulose Show Two Important Populations from Neutron Scattering and SimulationsCenter for Structural Molecular BiologySmall-Angle Neutron ScatteringSpallation Neutron Source/High Flux Isotope ReactorMolecular Structure
11/15/2017Cyanobacterial Studies Examine Cellular Structure During Nitrogen StarvationCenter for Structural Molecular BiologySmall-Angle Neutron ScatteringSpallation Neutron Source/High Flux Isotope ReactorMolecular Structure
12/13/2017Binding of Alternative Substrates to NitrogenaseStructural Molecular Biology ResourceX-ray Macromolecular CrystallographyStanford Synchrotron Radiation LightsourceMolecular Structure
01/17/2018"Zip Code" Mechanism for Hormone Signaling RevealedCenter for BioMolecular StructureX-ray Macromolecular CrystallographyNational Synchrotron Light Source II, Stanford Synchrotron Radiation LightsourceMolecular Structure
01/18/2018Structure of a Flavoenzyme Assembly IntermediateStructural Molecular Biology ResourceX-ray Macromolecular CrystallographyStanford Synchrotron Radiation LightsourceMolecular Structure
12/14/2017Using Plants to Immobilize and Stabilize Arsenic in the SoilCenter for BioMolecular Structure, Structural Molecular Biology ResourceX-ray Absorption and Emission Spectroscopy, X-ray Fluorescence ImagingNational Synchrotron Light Source II, Stanford Synchrotron Radiation LightsourceChemical and Elemental Information
08/30/2018Directed Evolution Mimics Allosteric Activation of EnzymesStructural Molecular Biology ResourceX-ray Macromolecular CrystallographyStanford Synchrotron Radiation LightsourceMolecular Structure
08/21/2018Potent BacteriaStructural Biology CenterX-ray Macromolecular CrystallographyAdvanced Photon SourceMolecular Structure
11/15/2018Controlled Self-Assembly of a Designed NucleoproteinStructural Molecular Biology ResourceSolution X-ray ScatteringStanford Synchrotron Radiation LightsourceMolecular Structure
02/05/2019Peptide Induced Lateral Segregation of Lipids in a BiomembraneCenter for Structural Molecular BiologySmall-Angle Neutron ScatteringSpallation Neutron Source/High Flux Isotope ReactorMolecular Structure
02/25/2019Breakthrough Shines Light on Disease-Fighting ProteinStanford-SLAC Cryo-EM Center, Structural Biology CenterCryo-Electron Microscopy, X-ray Macromolecular CrystallographyAdvanced Photon Source, Stanford Synchrotron Radiation LightsourceMolecular Structure
02/18/2019An Efficient and Economical Strategy for the Design of Functional MetalloproteinsStructural Molecular Biology ResourceX-ray Macromolecular CrystallographyStanford Synchrotron Radiation LightsourceMolecular Structure
02/22/2019DNA Gets a Bigger AlphabetStructural Molecular Biology ResourceX-ray Macromolecular CrystallographyStanford Synchrotron Radiation LightsourceMolecular Structure
03/05/2019Understanding Cadmium Distribution in Hyperaccumulating Plants for Efficient PhytoremediationStructural Molecular Biology ResourceX-ray Fluorescence ImagingStanford Synchrotron Radiation LightsourceChemical and Elemental Information
04/05/2019Influence of Chemically Disrupted Photosynthesis on Cyanobacterial Thylakoid DynamicsCenter for Structural Molecular BiologySmall-Angle Neutron ScatteringSpallation Neutron Source/High Flux Isotope ReactorMolecular Structure
04/12/2019What Enables the Fastest Carbon Dioxide Fixation by Reductive Carboxylase?Structural Molecular Biology ResourceX-ray Macromolecular CrystallographyStanford Synchrotron Radiation LightsourceMolecular Structure
05/03/2019New Approach for Solving Protein Structures from Tiny CrystalsCenter for BioMolecular StructureX-ray Macromolecular CrystallographyNational Synchrotron Light Source IIMolecular Structure
07/10/2019Structuring Sweetness: What Makes Stevia 200 Times Sweeter than Sugar?Structural Biology CenterX-ray Macromolecular CrystallographyAdvanced Photon SourceMolecular Structure
07/10/2019Structural Characterization of Chitinases from Agave tequilanaStructural Molecular Biology ResourceSolution X-ray ScatteringStanford Synchrotron Radiation LightsourceMolecular Structure
11/19/2019How Essential Membrane Lipids Interact to Regulate Cellular ProcessesStructural Biology CenterX-ray Macromolecular CrystallographyAdvanced Photon SourceMolecular Structure
11/29/2019Ammonia-Salt Solvent Promotes Cellulosic Biomass Deconstruction Under Ambient Processing ConditionsCenter for Structural Molecular BiologySmall-Angle Neutron ScatteringSpallation Neutron Source/High Flux Isotope ReactorMolecular Structure
12/09/2019Research at the Advanced Photon Source Leads to New Ebola DrugStructural Biology CenterX-ray Macromolecular CrystallographyAdvanced Photon SourceMolecular Structure
08/29/2020How Proteins Remodel DNA in Bacteria Under StressNational Center for X-Ray Tomography, Structurally Integrated Biology for the Life SciencesSolution X-ray Scattering, X-ray Macromolecular Crystallography, Soft X-ray TomographyAdvanced Light SourceMolecular Structure, Cell and Tissue Structure
08/13/2020Cell Membrane Proteins Imaged in 3DCenter for BioMolecular Structure, Structural Biology CenterX-ray Macromolecular Crystallography, X-ray Fluorescence ImagingAdvanced Photon Source, National Synchrotron Light Source IIChemical and Elemental Information
07/21/2020Role of Solvents in Efficient Biomass DeconstructionCenter for Structural Molecular BiologySmall-Angle Neutron ScatteringSpallation Neutron Source/High Flux Isotope ReactorMolecular Structure
02/14/2020How Dinosaur Blood Vessels Preserve Through the AgesBerkeley Synchrotron Infrared Structural Biology Imaging ProgramSynchrotron Infrared Hyperspectral ImagingAdvanced Light SourceChemical and Elemental Information
06/23/2020Novel Cell Membrane Model Could Be Key to Uncovering New Protein PropertiesCenter for BioMolecular Structure, Center for Structural Molecular BiologyCryo-Electron Microscopy, Small-Angle Neutron Scattering, Solution X-ray ScatteringNational Synchrotron Light Source II, Spallation Neutron Source/High Flux Isotope ReactorMolecular Structure, Cell and Tissue Structure
10/07/2020"Missing Link" in Evolutionary History of the Carbon-Fixing Protein RubiscoStructurally Integrated Biology for the Life SciencesSolution X-ray ScatteringAdvanced Light SourceMolecular Structure