Structural Molecular Biology Resource

About the Resource

The Structural Molecular Biology resource (SMB) integrates three cores of technological R&D and scientific focus to provide structural and functional details of biological materials across a broad range length and time scales. Located at SLAC National Accelerator Laboratory’s Stanford Synchrotron Radiation Lightsource (SSRL), SMB’s three core techniques are:

Significant synergy between the three cores enables an integrated research approach, with multiple methods used to address increasingly complex and challenging scientific problems that cannot be answered with a single methodology. Moreover, the unique properties of synchrotron radiation X-rays (extremely high intensity, tunability, and collimation) have helped overcome barriers to imaging and probing the macromolecular structure of biological materials, such as their weak interactions with X-rays and availability as scarce, small, dilute samples.

SMB operates seven dedicated beamlines (four MX, one SAXS, two XAS) and supports shared access to several other XAS/XES beamlines. The resource also partners in R&D and user support with the Linac Coherent Light Source facility’s Macromolecular Femtosecond Crystallography instrument.

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About the Home Facility

The Stanford Synchrotron Radiation Lightsource, at SLAC National Accelerator Laboratory, is a DOE scientific user facility sponsored by the Office of Basic Energy Sciences and operated by Stanford University. SSRL produces intense x-rays as a resource for scientists to study the world at the atomic and molecular levels, enabling research and advances in energy production, environmental remediation, nanotechnology, new materials, and medicine. SSRL operates approximately nine months each year, reliably delivering more than 97% of scheduled X-ray beam time.

Co-located BER Resources