Structurally Integrated Biology for the Life Sciences

About the Resource

The Structurally Integrated Biology for the Life Sciences (SIBYLS) beamline is a dual endstation synchrotron beamline combining X-ray macromolecular crystallography (MX) with small-angle X-ray scattering (SAXS) located at Lawrence Berkeley National Laboratory’s Advanced Light Source (ALS).

MX produces high-resolution structural information from biological molecules, and the high-throughput SAXS pipeline enables the same biological systems to be imaged in aqueous solution, which is closer to their natural environment.

Combining SAXS results with atomic-resolution structures provides detailed characterizations of mass, radius, conformation, assembly, and shape changes associated with protein folding and functions. SAXS can also resolve ambiguities of crystallography by showing the most likely possible structures.


About the Home Facility

The Advanced Light Source is a DOE scientific user facility at Lawrence Berkeley National Laboratory sponsored by the Office of Basic Energy Sciences. ALS is a specialized particle accelerator that generates bright beams of X-ray light for scientific research. Electron bunches travel at nearly the speed of light in a circular path, emitting ultraviolet and X-ray light in the process. The light is directed through about 40 beamlines to numerous experimental end stations, where scientists from around the world (“users”) can conduct research in a wide variety of fields, including materials science, biology, chemistry, physics, and the environmental sciences.

Co-located BER Resources

Other ALS Capabilities

ALS is home to several X-ray macromolecular crystallography (MX) beamlines. This technique can be used to visualize molecules at atomic resolution, enabling protein engineering, the design of therapeutics, and the fundamental understanding of enzyme mechanisms and protein function.